In recent years, many studies have been conducted about the measurement of recovery needs and about interventions to support regeneration. Among other approaches, the large research project REGman (www.regman.org; funded by the German Federal Institute of Sport Science) addresses these issues since 2012 with the participation of Saarland University (Meyer), Ruhr-University Bochum (Ferrauti, Kellmann) and Johannes Gutenberg-University Mainz (Pfeiffer). However, findings were far from homogeneous and considerable variability has been found among fatigue indicators as well as among athletes´ reponses to recovery interventions. Currently, only few methods can be recommended on the basis of clearly demonstrable average effects. Instead, individualization seems to be the most promising and most appropriate course to follow. For diagnostic purposes some algorithms have been developed already whereas there remains a lot of work to be done until non- and low-response are translated into prediction models valid for practical application.